Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC031
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-15 16:30
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment TBL MADOPAR 4X1\4 MADOPAR HBS 1 X1 DIFFICULTIES WITH ELEL

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.67 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.67 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 21, 'TP': 16, 'FP': 9}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 5, 'TP': 33, 'FP': 25}

Test Battery Details

Circle

numCircles 12
timePerCircleMean 9.89667
timePerCircleCoV 0.251786
timePerCircleSlope -0.0534615
meanError 4.77121
tremorFreq 6.54297
tremorRelPower 50.7479
tremorGyroAmpMean 0.0632085
tremorGyroAmpSlope -0.00194019
tremorGyroAmpCoV 0.450769
tremorCoordAmpMean 0.108642
tremorCoordAmpSlope -0.00266162
tremorCoordAmpCoV 0.436951
tremorAccAmpMean 0.103251
tremorAccAmpSlope -0.00342075
tremorAccAmpCoV 0.452068
tremorPcRelVar 0.734168
tremorPcX 0.399483
tremorPcY 0.91674

Circle Segment 1

Duration 10.8 s, Accuracy Estimate 5.454 (lower is better)

Circle Segment 2

Duration 11.68 s, Accuracy Estimate 6.374 (lower is better)

Circle Segment 3

Duration 13.12 s, Accuracy Estimate 4.625 (lower is better)

Circle Segment 4

Duration 13.4 s, Accuracy Estimate 3.874 (lower is better)

Circle Segment 5

Duration 13.6 s, Accuracy Estimate 3.108 (lower is better)

Circle Segment 6

Duration 7.72 s, Accuracy Estimate 3.802 (lower is better)

Circle Segment 7

Duration 9.4 s, Accuracy Estimate 5.837 (lower is better)

Circle Segment 8

Duration 8.56 s, Accuracy Estimate 4.138 (lower is better)

Circle Segment 9

Duration 7.6 s, Accuracy Estimate 5.89 (lower is better)

Circle Segment 10

Duration 7.16 s, Accuracy Estimate 4.083 (lower is better)

Circle Segment 11

Duration 8.08 s, Accuracy Estimate 4.421 (lower is better)

Circle Segment 12

Duration 7.64 s, Accuracy Estimate 5.65 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 34.9667
timePerSpiralCoV 0.178061
timePerSpiralSlope 0.0177475
meanError 2.69013
tremorFreq 5.95703
tremorRelPower 38.1336
tremorGyroAmpMean 0.0786142
tremorGyroAmpSlope 0.00116541
tremorGyroAmpCoV 0.503175
tremorCoordAmpMean 0.0922113
tremorCoordAmpSlope -0.000169416
tremorCoordAmpCoV 0.474961
tremorAccAmpMean 0.0864243
tremorAccAmpSlope -0.000326144
tremorAccAmpCoV 0.436195
tremorPcRelVar 0.648704
tremorPcX 0.207814
tremorPcY 0.978168

Spiral Segment 1

Duration 32.68 s, Accuracy Estimate 2.366 (lower is better)

Spiral Segment 2

Duration 40.12 s, Accuracy Estimate 2.214 (lower is better)

Spiral Segment 3

Duration 23.92 s, Accuracy Estimate 2.578 (lower is better)

Spiral Segment 4

Duration 41.12 s, Accuracy Estimate 3.566 (lower is better)

Spiral Segment 5

Duration 35.76 s, Accuracy Estimate 3.111 (lower is better)

Spiral Segment 6

Duration 36.2 s, Accuracy Estimate 2.305 (lower is better)

Elel

eDurationMean 0.820577
eDurationStd 0.335408
eDurationStdnorm 0.408747
eDurationMedian 0.6275
eDurationQuartdelta 0.565
eDurationQuartdeltanorm 0.900398
eDurationKurt 1.94217
eDurationTrenddiff -0.535
eDurationTrendratio 0.515837
eWidthMean 6.543
eWidthStd 3.73359
eWidthStdnorm 0.570624
eWidthMedian 5.4405
eWidthQuartdelta 3.978
eWidthQuartdeltanorm 0.731183
eWidthKurt 5.83773
eWidthTrenddiff -3.861
eWidthTrendratio 0.514706
eHeightMean 12.5685
eHeightStd 3.52901
eHeightStdnorm 0.280782
eHeightMedian 12.402
eHeightQuartdelta 4.563
eHeightQuartdeltanorm 0.367925
eHeightKurt 3.10684
eHeightTrenddiff 0.234
eHeightTrendratio 1.01905
eAspectMean 0.507789
eAspectStd 0.184534
eAspectStdnorm 0.363406
eAspectMedian 0.449613
eAspectQuartdelta 0.319094
eAspectQuartdeltanorm 0.709708
eAspectKurt 1.99909
eAspectTrenddiff -0.319094
eAspectTrendratio 0.519996
eSlantMean 0.0183123
eSlantStd 0.321009
eSlantStdnorm 17.5297
eSlantMedian -0.0249928
eSlantQuartdelta 0.500379
eSlantQuartdeltanorm -20.021
eSlantKurt 1.8999
eSlantTrenddiff -0.500379
eRtopMean 0.743453
eRtopStd 0.173742
eRtopStdnorm 0.233697
eRtopMedian 0.76777
eRtopQuartdelta 0.255583
eRtopQuartdeltanorm 0.33289
eRtopKurt 2.25529
eRtopTrenddiff -0.241758
eRbotMean 0.916461
eRbotStd 0.578994
eRbotStdnorm 0.631771
eRbotMedian 0.814704
eRbotQuartdelta 1.01964
eRbotQuartdeltanorm 1.25155
eRbotKurt 2.69728
eRbotTrenddiff 1.01964
eRrightMean 0.852516
eRrightStd 0.0867621
eRrightStdnorm 0.101772
eRrightMedian 0.865922
eRrightQuartdelta 0.0877311
eRrightQuartdeltanorm 0.101315
eRrightKurt 2.66269
eRrightTrenddiff -0.0465517
eRleftMean 0.390272
eRleftStd 0.180245
eRleftStdnorm 0.461845
eRleftMedian 0.463326
eRleftQuartdelta 0.311879
eRleftQuartdeltanorm 0.673132
eRleftKurt 1.95315
eRleftTrenddiff 0.311879
lDurationMean 0.963333
lDurationStd 0.63036
lDurationStdnorm 0.654353
lDurationMedian 0.6375
lDurationQuartdelta 0.765
lDurationQuartdeltanorm 1.2
lDurationKurt 4.9107
lDurationTrenddiff -0.7525
lDurationTrendratio 0.439479
lWidthMean 10.2034
lWidthStd 5.33055
lWidthStdnorm 0.52243
lWidthMedian 8.5995
lWidthQuartdelta 4.68
lWidthQuartdeltanorm 0.544218
lWidthKurt 5.55507
lWidthTrenddiff -3.744
lWidthTrendratio 0.666667
lHeightMean 19.7389
lHeightStd 5.37287
lHeightStdnorm 0.272197
lHeightMedian 18.5445
lHeightQuartdelta 6.201
lHeightQuartdeltanorm 0.334385
lHeightKurt 4.59901
lHeightTrenddiff -3.9195
lHeightTrendratio 0.810734
lAspectMean 0.50505
lAspectStd 0.163127
lAspectStdnorm 0.322991
lAspectMedian 0.459864
lAspectQuartdelta 0.162866
lAspectQuartdeltanorm 0.35416
lAspectKurt 5.17134
lAspectTrenddiff -0.114438
lAspectTrendratio 0.79447
lSlantMean 0.0177457
lSlantStd 0.262235
lSlantStdnorm 14.7774
lSlantMedian 0.00224921
lSlantQuartdelta 0.371706
lSlantQuartdeltanorm 165.261
lSlantKurt 2.87809
lSlantTrenddiff -0.253478
lRtopMean 0.678798
lRtopStd 0.203214
lRtopStdnorm 0.299374
lRtopMedian 0.703909
lRtopQuartdelta 0.311259
lRtopQuartdeltanorm 0.442187
lRtopKurt 2.34384
lRtopTrenddiff -0.171669
lRbotMean 0.698811
lRbotStd 0.35401
lRbotStdnorm 0.506589
lRbotMedian 0.686864
lRbotQuartdelta 0.58085
lRbotQuartdeltanorm 0.845655
lRbotKurt 2.52338
lRbotTrenddiff 0.425047
lRrightMean 0.828704
lRrightStd 0.106731
lRrightStdnorm 0.128793
lRrightMedian 0.855979
lRrightQuartdelta 0.195374
lRrightQuartdeltanorm 0.228246
lRrightKurt 1.50705
lRrightTrenddiff -0.0937006
lRleftMean 0.432228
lRleftStd 0.184081
lRleftStdnorm 0.425887
lRleftMedian 0.47027
lRleftQuartdelta 0.268717
lRleftQuartdeltanorm 0.571411
lRleftKurt 2.19107
lRleftTrenddiff 0.20204

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.673971
sumTouchScores 14.1534
meanMovementTime 0.98925
numTouches 21
undershootPercentage 4.7619
overshootPercentage 38.0952

FITTS Long Modified

meanTouchScore 0.694853
sumTouchScores 6.25368
meanMovementTime 1.8325
numTouches 9
undershootPercentage 22.2222
overshootPercentage 33.3333

ZigZag

numZigzags 4
timePerZigzagMean 22.25
timePerZigzagCoV 0.252768
timePerZigzagSlope -0.165573
meanError 4.36851
tremorFreq 5.85938
tremorRelPower 35.169
tremorGyroAmpMean 0.096928
tremorGyroAmpSlope 0.00419217
tremorGyroAmpCoV 0.31203
tremorCoordAmpMean 0.177549
tremorCoordAmpSlope 0.00500237
tremorCoordAmpCoV 0.326452
tremorAccAmpMean 0.159848
tremorAccAmpSlope 0.00432561
tremorAccAmpCoV 0.291273
tremorPcRelVar 0.733198
tremorPcX 0.129386
tremorPcY -0.991594

ZigZag Segment 1

Duration 30.6 s, Accuracy Estimate 6.406 (lower is better)

ZigZag Segment 2

Duration 20.6 s, Accuracy Estimate 3.86 (lower is better)

ZigZag Segment 3

Duration 18.92 s, Accuracy Estimate 3.472 (lower is better)

ZigZag Segment 4

Duration 18.88 s, Accuracy Estimate 3.736 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 18.912
timePerZigzagCoV 0.1192
timePerZigzagSlope -0.0418782
zigzagHeightMean 63.9842
zigzagHeightCoV 0.115677
zigzagHeightSlope -0.044257
meanError 0.044728
tremorFreq 5.85938
tremorRelPower 34.1484
tremorGyroAmpMean 0.0430032
tremorGyroAmpSlope 0.00442445
tremorGyroAmpCoV 0.419896
tremorCoordAmpMean 0.114531
tremorCoordAmpSlope 0.000402103
tremorCoordAmpCoV 0.306872
tremorAccAmpMean 0.110142
tremorAccAmpSlope 0.000397742
tremorAccAmpCoV 0.280832
tremorPcRelVar 0.873141
tremorPcX -0.24148
tremorPcY -0.970406

ZigZag Offset Segment 1

Duration 22.6 s, Accuracy Estimate 0.03 (lower is better)

ZigZag Offset Segment 2

Duration 18.52 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 3

Duration 16.8 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 4

Duration 17.48 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 5

Duration 19.16 s, Accuracy Estimate 0.092 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.67}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.863629552632472}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8224801436725133}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.524887181555026}